NFL Week 5 Final Injury Report: Key Injuries, Replacements & Sports Betting Impact
Sunday, October 11, 2026 | WANNA Make a Bet
With Week 5 underway, the NFL injury picture is considerably clearer. Several major players have been ruled out, multiple offensive lines are dealing with serious depth issues, and injuries to defensive secondaries could create favorable matchups for opposing offenses.
Our final report incorporates Sunday’s updated RotoWire injury data, confirmed inactive players for the early London game, and replacement analysis for the most consequential absences.
Top 5 NFL Week 5 Injury Headlines
1. Lamar Jackson OUT — Tyler Huntley Starts for Baltimore
Impact: SIGNIFICANT QB DOWNGRADE
Lamar Jackson will miss Baltimore’s Sunday night game against Atlanta with an ankle injury. Tyler Huntley takes over.
Huntley has NFL starting experience, but replacing Jackson changes Baltimore’s rushing threat, passing-game dynamics and overall offensive ceiling.
The Ravens also have center Cam Jurgens OUT and guard Andrew Vorhees Questionable.
Betting impact: Baltimore’s offense may need to rely more heavily on its running backs and shorter passing game. Huntley is a capable backup, but this is a meaningful downgrade from Jackson.
2. Chargers Offensive Line Severely Depleted Against Denver
Impact: MAJOR OFFENSIVE LINE CONCERN
The Chargers enter Sunday without Joe Alt, while Rashawn Slater is already sidelined. Guards Kayode Awosika and Trevor Penning are also unavailable.
The offensive line could require multiple replacements and positional adjustments.
Betting impact: Pass protection and offensive consistency are major concerns. However, Denver is also missing both Patrick Surtain II and Riley Moss at cornerback, creating a complicated matchup.
3. Philadelphia Missing Barkley, Smith, Brown and Greenard
Impact: MAJOR PERSONNEL LOSSES
The Eagles are without Saquon Barkley, DeVonta Smith, Hollywood Brown and center Drew Kendall. Edge rusher Jonathan Greenard is also inactive.
Will Shipley is expected to lead the backfield, while rookie Jake Majors steps in at center.
Betting impact: Philadelphia faces a combination of reduced offensive firepower, a reshuffled offensive line and a missing defensive pass rusher.
4. New England’s Cornerback Depth Is in Serious Trouble
Impact: MAJOR SECONDARY CONCERN
Christian Gonzalez, Carlton Davis, Channing Canada and Karon Prunty are all OUT. Charles Woods remains Questionable.
The Patriots could be forced deep into their cornerback depth chart.
Betting impact: Las Vegas may have opportunities to exploit replacement defensive backs, particularly if its offensive line provides adequate protection.
5. Minnesota Without Christian Darrisaw; Brian O’Neill Questionable
Impact: SIGNIFICANT TACKLE CONCERN
Starting left tackle Christian Darrisaw is OUT, while right tackle Brian O’Neill remains Questionable.
Justin Jefferson and Jordan Addison are also Questionable, making Minnesota’s offensive availability a significant pregame consideration.
Betting impact: Minnesota’s pass protection could be compromised even if its star receivers are active.
Week 5 Game-by-Game Injury Report
Philadelphia Eagles at Jacksonville Jaguars
Sunday, 9:30 AM ET — London
Injury Impact: VERY HIGH
Philadelphia Eagles
OUT / INACTIVE
- Saquon Barkley (RB) — Hamstring
- DeVonta Smith (WR) — Hamstring
- Hollywood Brown (WR) — Ankle
- Drew Kendall (C) — Knee
- Marcus Epps (S) — Groin
- Jonathan Greenard (LB/Edge) — Ankle
Replacement Analysis
Will Shipley takes on the lead backfield role, with Dameon Pierce and Carson Steele providing depth. Jake Majors makes his first NFL start at center.
Replacement impact: SIGNIFICANT TO MAJOR
Jacksonville Jaguars
OUT / INACTIVE
- Jaylon Jones (CB)
- Eric Murray (S)
Sports Betting Impact
Philadelphia has multiple offensive starters unavailable, including its primary running back and two important receivers. Losing Greenard further weakens the roster.
Jacksonville also has secondary injuries, but the Eagles have the more extensive overall personnel problem.
Key takeaway: Philadelphia’s offensive depth and ability to sustain drives are the biggest questions.
Cleveland Browns at New York Jets
Sunday, 1:00 PM ET
Injury Impact: HIGH
Cleveland Browns
OUT
- Mason Graham (DT)
- Mike Hall (DT)
- Teven Jenkins (G)
- Carsen Ryan (TE)
- Tylan Wallace (WR)
New York Jets
OUT
- Breece Hall (RB)
- Adonai Mitchell (WR)
- Dylan Parham (G)
- Kiko Mauigoa (LB)
QUESTIONABLE
- Kingsley Enagbare (DE)
- Will McDonald (DE)
Replacement Analysis
Braelon Allen is the primary backfield replacement to monitor for Breece Hall.
Replacement impact: MODERATE TO SIGNIFICANT
Sports Betting Impact
The Jets are missing several offensive contributors, but Cleveland has two defensive tackles OUT.
The Browns’ depleted interior defense could help offset the Jets’ loss of Hall.
Key takeaway: Watch how effectively New York can run against Cleveland’s weakened defensive interior.
Chicago Bears at Green Bay Packers
Sunday, 1:00 PM ET
Injury Impact: HIGH
Chicago Bears
QUESTIONABLE
- Caleb Williams (QB) — Hamstring
- Noah Sewell (LB)
OUT
- Kyle Monangai (RB)
- Keyshaun Elliott (LB)
Green Bay Packers
DOUBTFUL
- Aaron Banks (G)
- Jacob Monk (G)
QUESTIONABLE
- Jager Burton (C)
- Javon Hargrave (DT)
- Anthony Campbell (DT)
Replacement Analysis
If Caleb Williams cannot play, Tyson Bagent is Chicago’s established replacement.
Replacement impact: MODERATE TO SIGNIFICANT
Green Bay has two guards Doubtful and a center Questionable, potentially creating interior offensive-line instability.
Sports Betting Impact
Chicago’s quarterback decision is the most important outstanding issue.
Green Bay’s offensive-line injuries also deserve attention because multiple injuries to the same unit can have a greater impact than one isolated absence.
Key takeaway: Confirm Chicago’s starting QB and Green Bay’s starting offensive line before finalizing a wager.
Cincinnati Bengals at Miami Dolphins
Sunday, 1:00 PM ET
Injury Impact: HIGH
Cincinnati Bengals
QUESTIONABLE
- Ja’Marr Chase (WR) — Concussion
- Tee Higgins (WR) — Groin
- Colbie Young (WR)
- Bryan Cook (S)
- Swayze Bozeman (LB)
OUT
- Kyle Dugger (S)
Miami Dolphins
OUT
- Robert Beal (DE)
- Caleb Douglas (WR)
- Justin Joly (TE)
- Reese Taylor (CB)
QUESTIONABLE
- Jaylen Wright (RB)
- Jackson Woodard (LB)
Replacement Analysis
Andrei Iosivas is an important receiving option if Chase or Higgins cannot play.
Replacement impact:
- One starting receiver missing: SIGNIFICANT
- Both Chase and Higgins missing: MAJOR
Sports Betting Impact
Cincinnati’s injury uncertainty is concentrated at wide receiver.
Neither Chase nor Higgins should be considered out simply because they’re Questionable, but their availability could materially change the Bengals’ passing attack.
Key takeaway: Final confirmation on Chase and Higgins is essential.
Las Vegas Raiders at New England Patriots
Sunday, 1:00 PM ET
Injury Impact: VERY HIGH
Las Vegas Raiders
OUT
- Trey Zuhn (C)
- Jalen Nailor (WR)
QUESTIONABLE
- Ashton Jeanty (RB)
New England Patriots
OUT
- Christian Gonzalez (CB)
- Carlton Davis (CB)
- Channing Canada (CB)
- Karon Prunty (CB)
QUESTIONABLE
- Charles Woods (CB)
- Christian Barmore (DT)
- Rhamondre Stevenson (RB)
- Morgan Moses (OT)
- Christian Elliss (LB)
- Dre’Mont Jones (LB)
- Craig Woodson (S)
Replacement Analysis
New England has four cornerbacks ruled out and a fifth Questionable.
Replacement impact: MAJOR SECONDARY DEPTH CONCERN
Sports Betting Impact
This is one of the week’s most significant defensive injury concentrations.
New England could be forced to rely on less experienced defensive backs and change its coverage approach.
Las Vegas has its own issues at center and potentially running back.
Key takeaway: New England’s cornerback depth is a major matchup variable.
Minnesota Vikings at New Orleans Saints
Sunday, 1:00 PM ET
Injury Impact: VERY HIGH
Minnesota Vikings
OUT
- Christian Darrisaw (LT)
- Charles Demmings (CB)
QUESTIONABLE
- Brian O’Neill (RT)
- Justin Jefferson (WR)
- Jordan Addison (WR)
- Michael Jurgens (C)
- Ben Yurosek (TE)
New Orleans Saints
OUT
- Kaden Elliss (LB)
- Anfernee Jennings (LB)
- Jeremiah Wright (G)
QUESTIONABLE
- Alvin Kamara (RB)
- Julian Blackmon (S)
- Christen Miller (DT)
- Nathan Shepherd (DT)
- Vernon Broughton (DT)
- Jaylan Ford (LB)
- Barion Brown (WR)
- Lorenzo Styles (S)
Replacement Analysis
Minnesota must replace Darrisaw at left tackle. If O’Neill also misses the game, both tackle positions could require adjustments.
Replacement impact: SIGNIFICANT; potentially MAJOR if both tackles are unavailable.
Sports Betting Impact
Minnesota’s offensive line is the central concern, although the status of Jefferson and Addison could also affect the passing game.
New Orleans has injuries at linebacker and along the defensive interior.
Key takeaway: The Vikings’ final tackle combination is particularly important.
Houston Texans at Tennessee Titans
Sunday, 1:00 PM ET
Injury Impact: MEDIUM
Houston Texans
QUESTIONABLE
- Aireontae Ersery (OT)
- Blake Fisher (OT)
- Ed Ingram (G)
- Kayden McDonald (DT)
- M.J. Stewart (S)
Tennessee Titans
OUT
- Amani Hooker (S)
QUESTIONABLE
- Carnell Tate (WR)
- David Martin-Robinson (TE)
Sports Betting Impact
Houston has three offensive linemen listed as Questionable, although all three are dealing with illness rather than structural injuries.
Key takeaway: Houston’s offensive-line availability is worth checking, but Questionable does not necessarily mean those players will miss the game.
New York Giants at Washington Commanders
Sunday, 1:00 PM ET
Injury Impact: HIGH
New York Giants
OUT
- Jason Pinnock (S)
Washington Commanders
OUT
- Marcus Mariota (QB)
- Stefon Diggs (WR)
- Nick Cross (S)
- Percy Butler (S)
- Tyler Owens (S)
- Charles Omenihu (DE)
QUESTIONABLE
- Terry McLaurin (WR)
Replacement Analysis
Jayden Daniels is expected to start for Washington. With Mariota unavailable, rookie Athan Kaliakmanis is the backup to monitor.
Washington is also missing three safeties.
Replacement impact: MAJOR SECONDARY DEPTH CONCERN
Sports Betting Impact
Washington’s quarterback outlook has improved since Wednesday, but the Commanders still have significant defensive depth issues.
Key takeaway: Washington’s depleted safety group and McLaurin’s availability are the primary remaining concerns.
Indianapolis Colts at Pittsburgh Steelers
Sunday, 1:00 PM ET
Injury Impact: MEDIUM-HIGH
Indianapolis Colts
OUT
- Darius Slayton (WR)
- Ashton Dulin (WR)
- Jaylon Carlies (LB)
QUESTIONABLE
- Keenan Allen (WR)
- Charvarius Ward (CB)
Pittsburgh Steelers
OUT
- Jamel Dean (CB)
QUESTIONABLE
- Jalen Ramsey (S)
- Rico Dowdle (RB)
Sports Betting Impact
Indianapolis is missing two receivers, with Allen also Questionable. Pittsburgh is missing Dean, while Ramsey remains uncertain.
Key takeaway: Indianapolis’ available receivers against Pittsburgh’s potentially depleted secondary are the primary injury matchup.
Denver Broncos at Los Angeles Chargers
Sunday, 4:05 PM ET
Injury Impact: VERY HIGH
Denver Broncos
OUT
- Patrick Surtain II (CB)
- Riley Moss (CB)
Los Angeles Chargers
OUT
- Joe Alt (OT)
- Kayode Awosika (G)
- Donte Jackson (CB)
- Derwin James (S)
- Quentin Johnston (WR)
- Brenen Thompson (WR)
QUESTIONABLE
- Ladd McConkey (WR)
- Charlie Kolar (TE)
- Scott Matlock (FB)
- Rodney Shelley (CB)
- Branson Taylor (OT)
Additional depth concern: Rashawn Slater remains sidelined, and Trevor Penning has moved to injured reserve.
Replacement Analysis
The Chargers’ offensive line faces a major reshuffle. The team has lost both established tackles and has additional guard injuries.
Replacement impact: MAJOR.
Denver is also missing two key cornerbacks.
Replacement impact: SIGNIFICANT TO MAJOR SECONDARY CONCERN.
Sports Betting Impact
This is one of the most complicated injury matchups of Week 5.
The Chargers’ offensive line could struggle to protect Justin Herbert, while Denver’s secondary may be more vulnerable without Surtain and Moss.
Key takeaway: The impact of Denver’s pass rush against the Chargers’ replacement tackles could determine the game’s offensive rhythm.
Detroit Lions at Arizona Cardinals
Sunday, 4:25 PM ET
Injury Impact: MEDIUM-HIGH
Detroit Lions
OUT
- Ben Bartch (G)
- Rock Ya-Sin (CB)
QUESTIONABLE
- Tyleik Williams (DT)
Arizona Cardinals
OUT
- Marvin Harrison (WR) — Coach’s Decision
- Andrew Wingard (S)
QUESTIONABLE
- Walter Nolen (DT)
- Karson Sharar (LB)
Replacement Analysis
Arizona will need to redistribute receiving opportunities without Harrison, who is listed out for a coach’s decision rather than an injury.
Replacement impact: SIGNIFICANT OFFENSIVE ROLE CHANGE.
Sports Betting Impact
Harrison’s absence could change Arizona’s receiving rotation and passing-game distribution.
Key takeaway: Arizona’s offensive adjustments deserve attention, but Harrison should not be described as injured.
San Francisco 49ers at Seattle Seahawks
Sunday, 4:25 PM ET
Injury Impact: HIGH
San Francisco 49ers
OUT
- Nick Bosa (DE)
- James Thompson (DT)
- Kyle Juszczyk (FB)
- Marques Sigle (S)
QUESTIONABLE
- Upton Stout (CB)
Seattle Seahawks
OUT
- Chazz Surratt (LB)
QUESTIONABLE
- George Holani (RB)
Replacement Analysis
San Francisco is missing two defensive linemen, including its premier pass rusher.
Replacement impact: SIGNIFICANT DEFENSIVE FRONT DOWNGRADE.
Juszczyk’s absence also affects San Francisco’s offensive versatility.
Sports Betting Impact
Seattle could benefit from a weakened San Francisco pass rush.
Key takeaway: The 49ers’ defensive front is the primary injury concern.
Baltimore Ravens at Atlanta Falcons
Sunday, 8:20 PM ET
Injury Impact: VERY HIGH
Baltimore Ravens
OUT
- Lamar Jackson (QB)
- Cam Jurgens (C)
- Trey Hendrickson (LB/Edge)
QUESTIONABLE
- Andrew Vorhees (G)
- Marlon Humphrey (CB)
- Zay Flowers (WR)
Atlanta Falcons
OUT
- Za’Darius Smith (LB/Edge) — Concussion
QUESTIONABLE
- Jake Matthews (LT)
- Divine Deablo (LB)
- Samson Ebukam (LB)
Replacement Analysis
Tyler Huntley will start in place of Lamar Jackson.
Replacement impact: SIGNIFICANT QB DOWNGRADE.
Baltimore is also missing its center, and Vorhees remains Questionable.
Atlanta has its own edge-rushing concerns, with Smith out and Ebukam Questionable.
Sports Betting Impact
Baltimore’s quarterback change is the biggest confirmed individual injury adjustment remaining on Sunday’s schedule.
Huntley’s experience provides some stability, but Jackson’s absence changes the offensive ceiling.
Key takeaway: Baltimore’s offensive performance with Huntley, especially behind a potentially weakened line, is the central betting consideration.
Buffalo Bills at Los Angeles Rams
Monday, 8:15 PM ET
Injury Impact: MEDIUM-HIGH
Buffalo Bills
OUT
- Ed Oliver (DT) — Knee
- Joshua Palmer (WR) — Shoulder
QUESTIONABLE
- Dee Alford (CB)
- Landon Jackson (DE)
- DJ Moore (WR)
Los Angeles Rams
QUESTIONABLE
- Quentin Lake (S)
Replacement Analysis
Oliver’s absence is significant for Buffalo’s defensive interior.
Replacement impact: MODERATE TO SIGNIFICANT.
Palmer’s absence also affects Buffalo’s receiver depth, particularly with DJ Moore Questionable.
Sports Betting Impact
Buffalo’s defensive front and receiving depth are the main injury concerns entering Monday night.
The Rams have a relatively limited list of current game-status designations.
Key takeaway: Oliver being ruled out is the biggest change from Saturday’s report and could affect Buffalo’s ability to control the line of scrimmage.
Final Week 5 Sports Betting Outlook
The most important lesson from this week’s injury report is that the impact of an injury depends on who replaces the missing player and how much depth remains behind him.
Lamar Jackson’s absence creates a significant quarterback downgrade. The Chargers’ offensive line has multiple simultaneous personnel problems. Philadelphia is missing important contributors across several offensive positions, while New England and Denver have major cornerback concerns.
These situations deserve more attention than isolated Questionable designations.
For bettors, the final step is confirming the official inactive lists approximately 90 minutes before kickoff. A Questionable player may be active, but that still does not guarantee a full workload or unrestricted performance.
At WANNA Make a Bet, we focus on the injuries that can actually change the handicap—not simply the longest injury lists.
Updated October 11, 2026. Sources: RotoWire NFL Injury Report, official NFL Week 5 injury designations and team announcements. Replacement-impact assessments are editorial evaluations, not official player grades. All times Eastern.