Week 6 Final NFL Injury Report: The Absences That Could Change Sunday’s Games

October 18, 2026 | Wannamakeabet.com

Quarterbacks are driving the Week 6 injury conversation, but some of Sunday’s biggest matchup problems start up front. Missing tackles, depleted defensive lines and several important suspensions could have just as much influence on how these games unfold.

Here’s our final Sunday morning report, covering all 12 games on today’s schedule. Questionable players still require confirmation when inactive lists are released, approximately 90 minutes before kickoff. Takeaways reflect the potential matchup impact, rather than automatic picks.

The Five Biggest Headlines

1. Philadelphia turns to Tanner McKee. Jalen Hurts is on injured reserve, and Saquon Barkley is also out.
2. Baltimore remains without Lamar Jackson. Tyler Huntley starts again, with additional concerns along the Ravens’ interior offensive line.
3. Baker Mayfield misses another game. Rookie Jalon Daniels gets another start for Tampa Bay.
4. Caleb Williams is expected back. Chicago’s quarterback return comes as its defense loses Montez Sweat to suspension.
5. The Chargers’ protection problems keep growing. Joe Alt is out, joining Rashawn Slater and multiple interior linemen on the sidelines.

Houston Texans at Jacksonville Jaguars — 9:30 a.m. ET

Texans: RB David Montgomery is OUT with a groin injury. Houston also remains without WR Jayden Higgins, while Tank Dell has not returned to action. Those absences reduce both backfield options and receiving depth.

Jaguars: OT Anton Harrison is on IR, and guard Patrick Mekari remains unavailable on injured reserve. CB Montaric Brown is OUT, with CB Jaylon Jones QUESTIONABLE, creating an additional concern against Houston’s passing game.

WANNA takeaway: Jacksonville’s weakened protection and Houston’s missing offensive weapons make sustained execution a bigger concern than either team’s full-strength reputation suggests.

Baltimore Ravens at Cleveland Browns — 1 p.m. ET

Ravens: QB Lamar Jackson is OUT with an ankle injury, leaving Tyler Huntley to start. Center Cam Jurgens is also OUT, while guards Emery Jones and Andrew Vorhees are QUESTIONABLE. Defensive lineman Broderick Washington is OUT.

Browns: RB Quinshon Judkins is QUESTIONABLE, with Dylan Sampson still unavailable. Guard Teven Jenkins and DT Mike Hall are OUT; DT Mason Graham and DE Derek Barnett are QUESTIONABLE. Cleveland’s defensive line could be significantly thinner if those decisions go against it.

WANNA takeaway: Huntley playing behind a compromised interior line gives Cleveland an opportunity, but the Browns need their own questionable defensive linemen available to capitalize.

Carolina Panthers at Philadelphia Eagles — 1 p.m. ET

Panthers: OT Ikem Ekwonu remains unavailable, and OT Monroe Freeling is DOUBTFUL. OT Taylor Moton and guard Damien Lewis are QUESTIONABLE, as are edge rusher Jaelan Phillips and DT Tershawn Wharton. WR Xavier Legette and RB Jonathon Brooks remain on IR.

Eagles: QB Jalen Hurts is on IR because of a superficial blood clot in his calf, putting Tanner McKee in the starting lineup. RB Saquon Barkley is OUT, with Tank Bigsby and Will Shipley also unavailable. Guard Landon Dickerson remains out, center Drew Kendall is QUESTIONABLE, and Lane Johnson is listed unavailable in the supplied report.

WANNA takeaway: Philadelphia’s combined losses at quarterback, running back and offensive line substantially lower its offensive ceiling, although Carolina’s tackle problems offer the Eagles a way to disrupt the game.

Chicago Bears at Atlanta Falcons — 1 p.m. ET

Bears: QB Caleb Williams remains officially QUESTIONABLE, but is expected to start after practicing fully. RB Kyle Monangai is OUT. DE Montez Sweat is SUSPENDED, DE Dayo Odeyingbo is on IR, and LB T.J. Edwards is OUT, leaving Chicago short of important front-seven personnel.

Falcons: Edge rusher James Pearce is listed SUSPENDED, Jalon Walker remains on IR, and Za’Darius Smith is QUESTIONABLE. Atlanta also lacks CB A.J. Terrell and has ruled out C.J. Henderson. QB Michael Penix Jr. carries no game designation following his rib issue.

WANNA takeaway: Williams’ expected return helps Chicago against Atlanta’s depleted secondary, while the Bears’ missing defensive starters create a favorable opening for the Falcons’ offense.

New Orleans Saints at New York Giants — 1 p.m. ET

Saints: RB Alvin Kamara is QUESTIONABLE with a back injury, and WR Chris Olave is QUESTIONABLE with an illness. RB Travis Etienne remains on IR. OT Kelvin Banks and guard Dillon Radunz are also unavailable, while DT Bryan Bresee’s absence and Nathan Shepherd’s questionable status weaken the defensive interior.

Giants: QB Jaxson Dart remains on IR. Tackles Andrew Thomas and Jermaine Eluemunor are QUESTIONABLE, and TE Theo Johnson is OUT. Edge rusher Brian Burns remains on IR, with Abdul Carter QUESTIONABLE.

WANNA takeaway: Kamara and Olave’s availability could swing this matchup, but both offenses face protection concerns that make clean, consistent drives difficult to assume.

New York Jets at New England Patriots — 1 p.m. ET

Jets: RB Breece Hall, WR Adonai Mitchell and guard Dylan Parham are OUT. WR Omar Cooper and TE Kenyon Sadiq are QUESTIONABLE. DT David Onyemata remains on IR, and DE Joseph Ossai is OUT.

Patriots: WR A.J. Brown has been activated from IR, setting up his return, although a full workload is uncertain. RB TreVeyon Henderson and LT Will Campbell remain QUESTIONABLE; New England’s Saturday roster decisions suggest both are trending toward playing. Guards Mike Onwenu and Greg Van Roten remain unavailable.

WANNA takeaway: Brown’s return improves New England’s options against a Jets team missing Hall and Parham, but the Patriots’ offensive line remains a potential obstacle.

Pittsburgh Steelers at Tampa Bay Buccaneers — 1 p.m. ET

Steelers: WR Michael Pittman remains on IR, joining Roman Wilson among the unavailable receivers, while Ben Skowronek is OUT. TE Pat Freiermuth and RB Rico Dowdle are QUESTIONABLE. Up front, DT Derrick Harmon remains on IR, and Keeanu Benton is QUESTIONABLE.

Buccaneers: QB Baker Mayfield is OUT with a thumb injury, and Jalon Daniels will start again. WR Jalen McMillan remains on IR, and RB Sean Tucker is QUESTIONABLE. Tampa Bay also loses safety Antoine Winfield Jr., while CB Benjamin Morrison is DOUBTFUL.

WANNA takeaway: Tampa Bay’s rookie quarterback faces a difficult assignment, but Pittsburgh’s missing receivers and questionable supporting weapons complicate its ability to pull away.

Tennessee Titans at Indianapolis Colts — 1 p.m. ET

Titans: RB Tyjae Spears is QUESTIONABLE with a knee injury. Guards Jackson Slater and Fernando Carmona remain on IR, reducing interior depth. DT Jordan Elliott is OUT for personal reasons, and edge rusher Jaylen Harrell remains on IR.

Colts: TE Tyler Warren is QUESTIONABLE with a groin injury. WR Alec Pierce remains on IR, WR Ashton Dulin is OUT, and DE Arden Key remains unavailable on injured reserve.

WANNA takeaway: Warren’s availability matters to Indianapolis’ passing options, while Tennessee’s offensive line attrition increases the difficulty of keeping its offense on schedule.

Arizona Cardinals at Los Angeles Rams — 4:05 p.m. ET

Cardinals: RB Jeremiyah Love is OUT, with James Conner still unavailable and Trey Benson on IR. OT Paris Johnson and guards Isaiah Adams and Chase Bisontis are also on IR. Safety Budda Baker and edge defender Zaven Collins are QUESTIONABLE.

Rams: LT Alaric Jackson is SUSPENDED for this game. Pass rusher Myles Garrett remains on IR, while CB Trent McDuffie and safety Kam Curl are QUESTIONABLE. TE Terrance Ferguson is also on IR. Jackson’s suspension was reduced on appeal, but he still misses Week 6.

WANNA takeaway: Arizona’s depleted backfield and offensive line are major concerns, though the Rams’ missing left tackle and defensive questions give the Cardinals opportunities to stay competitive.

Buffalo Bills at Las Vegas Raiders — 4:25 p.m. ET

Bills: WRs DJ Moore and Joshua Palmer are QUESTIONABLE with shoulder injuries. DTs Ed Oliver and T.J. Sanders are also QUESTIONABLE, making the interior defensive rotation another important pregame watch.

Raiders: WR Jack Bech remains on IR, and Dont’e Thornton remains unavailable. DT Tonka Hemingway is OUT with a concussion, while center Trey Zuhn is QUESTIONABLE.

WANNA takeaway: Buffalo’s receiver availability could change its offensive approach, while Oliver and Sanders’ status will help determine how well the Bills can control the line of scrimmage.

Los Angeles Chargers at Kansas City Chiefs — 4:25 p.m. ET

Chargers: OT Joe Alt and guard Kayode Awosika are OUT, adding to an offensive line already missing Rashawn Slater, Tyler Biadasz, Trevor Penning and Trey Pipkins. WR Tre’ Harris is OUT, and TE David Njoku remains on IR. DTs Dalvin Tomlinson and Jamaree Caldwell are QUESTIONABLE; safety Derwin James and CB Donte Jackson are OUT.

Chiefs: WR Rashee Rice and OT Josh Simmons are OUT. CB L’Jarius Sneed is QUESTIONABLE.

WANNA takeaway: The Chargers’ extensive protection losses and missing secondary starters create problems on both sides of the ball, even with Kansas City missing Rice and Simmons.

Dallas Cowboys at Green Bay Packers — 8:20 p.m. ET

Cowboys: DT Jonathan Bullard remains on IR, while defensive lineman LT Overton is QUESTIONABLE. CB Cobie Durant is OUT, and CB Joey Porter is QUESTIONABLE. The supplied report lists LB DeMarvion Overshown as OUT, although the league’s injury page still shows him questionable.

Packers: RB Josh Jacobs remains unavailable on the commissioner exempt list for this game; his removal takes effect Monday. WR Jayden Reed is on IR, with Skyy Moore also unavailable and Savion Williams QUESTIONABLE. Green Bay is missing DTs Javon Hargrave and Jonathan Ford, while guard Aaron Banks is QUESTIONABLE.

WANNA takeaway: Green Bay’s missing running back and defensive tackles, combined with Dallas’ secondary concerns, put added pressure on both passing games to carry the night.

Before locking in your WANNA picks: Recheck the questionable players, especially New Orleans’ Kamara and Olave, Buffalo’s receivers, and the offensive linemen whose availability could change an entire game plan.

Bring your picks—and your arguments—to Wannamakeabet.com, where the competition runs on fantasy points and bragging rights.