Chargers vs Jags Betting Preview – November 16, 2025

Los Angeles
@

Jacksonville
Sunday, November 16, 2025 at 1:00 PM ET

NFL Schedule

  • Los Angeles Chargers @ Jacksonville Jaguars on Sunday, Nov 16, 2025 at 10:00 AM PST

Introduction

The Los Angeles Chargers (7-3) are set to face the Jacksonville Jaguars (5-4) on Sunday, November 16, 2025, at EverBank Stadium in Jacksonville, Florida. Kickoff is scheduled for 1:00 PM EST. The Chargers enter the game as 3-point favorites, with the over/under set at 43.5 points. This matchup presents intriguing betting opportunities, considering both teams’ recent performances and injury reports.

Team Analysis

Los Angeles Chargers

Season Overview and Recent Form

The Chargers have demonstrated a strong season, holding a 7-3 record. Their offense ranks 8th in the league, averaging 24 points per game, while their defense is even more impressive, ranking 4th overall and 5th against the pass. In their most recent game, they secured a 25-10 victory over the Pittsburgh Steelers, showcasing both offensive efficiency and defensive prowess.

Injuries and News

The Chargers have faced challenges on the offensive line, with season-ending injuries to key players. To bolster their protection, they acquired offensive tackle Trevor Penning from New Orleans at the trade deadline. Penning is expected to make his debut in this game, potentially providing a significant boost to the Chargers’ offensive line.

Jacksonville Jaguars

Season Overview and Recent Form

The Jaguars have had an up-and-down season, currently standing at 5-4. Their offense averages 22.8 points per game, ranking 23rd in the league, while their defense allows 24.4 points per game, placing them 20th. In their last outing, they suffered a 36-29 loss to the Houston Texans, indicating potential vulnerabilities in both offensive and defensive units.

Injuries and News

The Jaguars have been hit hard by injuries. Rookie wide receiver Travis Hunter underwent surgery to repair a lateral collateral ligament in his right knee and is expected to miss the remainder of the season. Additionally, tight end Brenton Strange has been activated from the 21-day practice window after recovering from a quadriceps injury, though his availability for this game remains uncertain.

Key Matchup Factors

Head-to-Head History

The Chargers lead the all-time series against the Jaguars 9-4. In their most recent encounter on January 14, 2023, the Jaguars emerged victorious in Jacksonville.

Important Player Matchups

  • Justin Herbert vs. Trevor Lawrence: Herbert has been instrumental in the Chargers’ success, with 2,610 passing yards, 19 touchdowns, and 8 interceptions this season. Lawrence, on the other hand, has thrown for 1,998 yards, 10 touchdowns, and 7 interceptions. Herbert’s experience and consistency may give the Chargers an edge in this matchup.
  • Keenan Allen vs. Jaguars Secondary: Allen leads the Chargers with 30 receptions for 420 yards and 14 yards per catch this season. The Jaguars’ secondary, dealing with injuries and inconsistencies, may struggle to contain Allen, potentially allowing him to exploit mismatches.

Injuries and News

The Chargers’ acquisition of Trevor Penning could stabilize their offensive line, providing better protection for Herbert and enhancing the running game. For the Jaguars, the absence of Travis Hunter and the uncertain status of Brenton Strange could impact their offensive dynamics, especially in the passing game.

Home/Away Performance

The Chargers have a strong road record at 3-1, with an average margin of victory of 6.7 points per game. The Jaguars, while 3-2 at home, have shown vulnerabilities, particularly in their recent loss to the Texans.

Betting Analysis

Spread Analysis

The Chargers are favored by 3 points. Given their superior record, offensive efficiency, and the potential impact of Penning’s debut, they are well-positioned to cover the spread.

Total (Over/Under) Analysis

The over/under is set at 43.5 points. Both teams have shown the ability to score, with the Chargers averaging 24 points per game and the Jaguars averaging 22.8. Considering the Chargers’ offensive capabilities and the Jaguars’ need to compensate for injuries, the over appears to be a reasonable consideration.

Best Value Opportunities

  • Keenan Allen Over 41.5 Receiving Yards: Allen has been a consistent target for Herbert and is likely to see increased opportunities against a banged-up Jaguars secondary.
  • Oronde Gadsden Anytime Touchdown: The Jaguars have struggled against tight ends, allowing seven touchdowns to the position in nine games. Gadsden, with his red zone presence, could capitalize on this weakness.

Prediction

The Los Angeles Chargers are poised to extend their winning streak to four games with a victory over the Jacksonville Jaguars. Their balanced offense, bolstered by the addition of Trevor Penning, and a defense that ranks among the league’s best, provide a solid foundation for success. The Jaguars, dealing with significant injuries and inconsistencies, face an uphill battle. While they have the potential to keep the game competitive, the Chargers’ overall strength and recent form make them the favored team in this matchup.

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